Uses and studies of melatonin

Uses and melatonin studies on Medline PlusUso based on scientific evidence have been tested for the following uses of melatonin in humans or animals. The safety and effectiveness have not always been proven. Some of these conditions are potentially serious and should be evaluated by a qualified healthcare provider.

Synonyms: 5-Methoxy-N-acetiltriptamina, acetamide, beta-methyl-6-cloromelatonina, BMS-214778, luzindole, mel, MEL, melatonin, MLT, N-acetyl-5-methoxytryptamine, N-2-(5-metoxindol -3-ethyl)-acetamide, Ramelteon (TAK-375) receptor selective agonist MT1/MT2).

Jetlag (jet lag) Several randomized placebo-controlled in humans suggest that melatonin taken by mouth, started the day of travel (close to bedtime at the destination) and continued for several days, reduces the number of days required to establish a normal sleep pattern, shortens the time needed to fall asleep ("sleep latency"), improves alertness and reduces fatigue during the day. However these results are compelling, most studies have had methodological problems with the design and how to present the results, while some studies have found no benefits for the use of melatonin. In general, the scientific evidence does suggest benefits of melatonin for up to half of people who take it to jet lag (jet lag). More trials are needed to confirm these findings, determine the optimal dosage and evaluate the use in combination with sleep aids that are sold by prescription. Grade A

Syndrome delayed sleep phase syndrome delayed sleep phase is a condition that results in delay in falling asleep, despite normal sleep patterns and sleep duration. Although these results are promising, additional research is needed larger studies before making a stronger recommendation. Grade B Sleep disturbances in children with neuropsychiatric disorders Several controlled trials and case reports of melatonin use in children with various neuro-psychiatric disorders, including mental retardation, autism, psychiatric disorders, visual impairment or epilepsy. Studies have shown a decreased time to sleep (sleep latency) and increased sleep duration. It is well-designed controlled trials in patient populations selected before a stronger recommendation or more specific. Grade B Insomnia in the elderly Several human studies report that melatonin taken by mouth between 30 and 120 minutes before bedtime decreases the time needed to fall asleep ("sleep latency") in elderly insomniacs, however, studies have not been a lot of quality in their designs and some research have found little or no benefit.

Most trials are of short duration (several days), so the unknown long-term effects. Grade B improved sleep in healthy individuals Several studies have measured the effects of melatonin supplements on sleep in healthy individuals have used a wide range of doses, often orally 30 to 60 minutes before bedtime . Most trials are small and short, and without a design or rigorous reporting method. However, the weight of scientific evidence does suggest that melatonin reduces the time needed to fall asleep ("sleep latency"), increases the feeling of "sleepiness" and may increase sleep duration. Better research is needed in this area. Grade B * Key to grades: Grade A: Strong scientific evidence for this use Grade B: Good scientific evidence for this use Drug Administration U.S. Food and (FDA) does not regulate herbs and supplements strictly. There is no guarantee of strength, purity or safety of products, and effects may vary. Always read product labels.

If you have a medical condition or are taking other drugs, herbs or supplements, you should consult with a qualified healthcare provider before starting a new therapy. Consult a doctor immediately if you experience side effects.